Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.
نویسندگان
چکیده
We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide. We describe a possible drug interaction between these two drugs and recommend that they should only be used together with caution.
منابع مشابه
Hyponatraemia induced by low-dose intravenous pulse cyclophosphamide.
BACKGROUND Cyclophosphamide is an alkylating agent and was traditionally known to potentiate the renal action of vasopressin. Although low-dose intravenous pulse cyclophosphamide therapy is being used extensively in the treatment of malignant and rheumatological diseases, there have been only a few case reports of cyclophosphamide-induced hyponatraemia. METHODS Clinical data were retrospectiv...
متن کاملCyclophosphamide-induced symptomatic hyponatraemia.
Cyclophosphamide is an alkylating agent used in antineoplastic and immunosuppressive therapies. Symptomatic hyponatraemia is a rare but life-threatening complication in patients treated with cyclophosphamide. We report the case of a 64-year-old woman with breast cancer who developed severe symptomatic hyponatraemia with a generalised seizure and convulsions after a second cycle of adjuvant chem...
متن کاملLife-Threatening Acute Hyponatremia with Generalized Seizure Induced by Low-Dose Cyclophosphamide in a Patient with Breast Cancer
Cyclophosphamide is commonly used in the treatment of malignant diseases. Symptomatic severe hyponatremia induced by low-dose cyclophosphamide is very uncommon worldwide. Recently we experienced a case of a 56-year-old woman with breast cancer who developed severe hyponatremia with generalized seizure after the first cycle of adjuvant chemotherapy with doxorubicin and cyclophosphamide. Her labo...
متن کاملInsight on mechanism of hyponatraemia induced by low-dose intravenous pulse cyclophosphamide.
Sir, We read with great interest the recent contribution by Lee et al. [1]. The authors showed significant clinical data on hyponatraemia induced by low-dose intravenous pulse cyclophosphamide (CYP) [1]. However, they did not reveal precise and molecular-based mechanisms of hyponatraemia induced by CYP. We would like to add some possible mechanisms of CYP-induced hyponatraemia. Firstly, they sp...
متن کاملCyclophosphamide-Induced Severe Acute Hyponatremic Encephalopathy in Patients with Breast Cancer: Report of Two Cases
BACKGROUND Cyclophosphamide is an alkylating agent widely used in antineoplastic and immunosuppressive therapies. Symptomatic hyponatremia can be a rare but life-threatening complication in patients treated with cyclophosphamide. CASE PRESENTATIONS We report 2 patients who presented with severe acute hyponatremic encephalopathy after receiving their first cycles of a low-dose cyclophosphamide...
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ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 65 770 شماره
صفحات -
تاریخ انتشار 1989